Top quality factory supply 23426-63-3 Methyl 2-bromo-2-methylpropionate at low price
- Molecular Formula:C5H9BrO2
- Molecular Weight:181.029
- Appearance/Colour:powder
- Vapor Pressure:4.77mmHg at 25°C
- Refractive Index:n20/D 1.451
- Boiling Point:145.8 °C at760mmHg
- Flash Point:49 °C
- PSA：26.30000
- Density:1.416 g/cm3
- LogP:1.33290
Methyl 2-bromo-2-methylpropionate(Cas 23426-63-3) Usage
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Synthesis
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Bromoisobutyric acid (4.17 g, 25 mmol) was dissolved in a solution of concentrated sulfuric acid (0.75 mL) and methanol (50 mL) and stirred under reflux for 2 h. The solution was then cooled to room temperature and concentrated under vacuum. The residue was dissolved in diethyl ether and washed with 10% aqueous sodium bicarbonate, washed with brine, dried under magnesium sulfate, and concentrated again under vacuum. A colorless oil was obtained (4.2 g, 23 mmol, 93% yield)?1H NMR (300 MHz, CDCl3) δ(ppm): 3.78 (s, 3H), 1.93 (s, 6H) |
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Synthesis Reference(s)
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The Journal of Organic Chemistry, 43, p. 3684, 1978 DOI: 10.1021/jo00413a009 |
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Application
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Methyl 2-bromo-2-methylpropionate can be used as a free radical initiator to participate in polymerization reactions. |
InChI:InChI=1/C5H9BrO2/c1-5(2,6)4(7)8-3/h1-3H3
23426-63-3 Relevant articles
1,2-Dibromoethane in the Synthesis of 2-Bromoesters: Bromination vs Alkylation
Ibarzo, Javier,Ortuno, Rosa M.
, p. 9825 - 9830 (1994)
1,2-Dibromoethane has been employed as a...
Activating ATRP Initiators to Incorporate End-Group Modularity into Photo-RAFT Polymerization
Hakobyan, Karen,McErlean, Christopher S. P.,Müllner, Markus
, p. 10357 - 10365 (2020)
Heterogeneous photocatalysis is increasi...
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Gensler,W.J. et al.
, p. 4279 - 4281 (1968)
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Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992
Kharade, Sujay V.,Kurata, Haruto,Bender, Aaron M.,Blobaum, Anna L.,Figueroa, Eric E.,Duran, Amanda,Kramer, Meghan,Days, Emily,Vinson, Paige,Flores, Daniel,Satlin, Lisa M.,Meiler, Jens,Weaver, C. David,Lindsley, Craig W.,Hopkins, Corey R.,Denton, Jerod S.
supporting information, p. 926 - 937 (2018/08/04)
The inward rectifier potassium (Kir) cha...
23426-63-3 Process route
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2052-01-9
2-bromo-2-methylpropionic acid
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23426-63-3
2-bromo-2-methylpropionic acid methyl ester
Conditions
| Conditions |
Yield |
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With
sulfuric acid;
for 2h;
Reflux;
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93%
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With
hydrogenchloride;
In
dichloromethane;
at 20 ℃;
for 23h;
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70%
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23426-63-3
2-bromo-2-methylpropionic acid methyl ester
Conditions
| Conditions |
Yield |
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With
phosphorus; bromine;
at 70 - 80 ℃;
anschliessende Veresterung mit Methanol;
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23426-63-3 Upstream products
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67-56-1
methanol
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20469-89-0
2-bromo-2-methylpropionyl chloride
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5634-54-8
1,1-dimethoxy-2-methylprop-1-ene
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2589-57-3
dimethyl 2,2'-azobis(isobutyrate)
23426-63-3 Downstream products
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91555-98-5
2-(3,5-dimethoxyphenoxy)-2-methylpropanoic acid
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97798-58-8
3-hydroxy-2,2-dimethyl-4-phenylpentanoate
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140653-59-4
α-dimethylamino-isobutyric acid methyl ester
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14002-80-3
Methyl 2,2-dimethyl-3-hydroxypropionate
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