
Mobile/Wechat/WhatsApp: Chen Shihuai +86-13961989018 Yang Zhengquan +86-13921613169 Chen Yi +86-13962066393
CasNo: 104-92-7
Molecular Formula: C7H7BrO
Appearance: colourless liquid
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Synthesis Reference(s) |
Tetrahedron Letters, 35, p. 7429, 1994 DOI: 10.1016/0040-4039(94)85333-9Synthesis, p. 868, 1986 DOI: 10.1055/s-1986-31813 |
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Safety Profile |
Moderately toxic by ingestion andintraperitoneal routes. When heated to decomposition itemits toxic vapors of Br-. |
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Purification Methods |
Crystallise the anisole by repeated partial freezing, then distil it under reduced pressure. [Beilstein 6 III 741, 6 IV 1044.] |
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Definition |
ChEBI: A monomethoxybenzene carrying a bromo substituent at position 4. |
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General Description |
4-Bromoanisole is a useful brominating reagent. It is formed as reaction product in the reaction between HOBr and anisole. Suzuki coupling of 4-bromoanisole with phenylboronic acid catalyzed by palladium pincer complexes has been studied. Heck Reaction of 4-bromoanisole with ethyl acrylates in room-temperature ionic liquids is reported to afford ethyl 4-methoxycinnamate. |
InChI:InChI=1/C7H7BrO/c1-9-7-4-2-6(8)3-5-7/h2-5H,1H3
We describe the dehydroxymethylbrominati...
In this Letter, a copper-catalyzed halog...
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Interhalogen fluorides (XF; X = I, Br, o...
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A novel and efficient catalytic system f...
A simple, efficient and rapid method has...
Reactivity-structure correlations for an...
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Direct bromination of a wide range of ar...
A new method of brominating aromatic and...
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An efficient catalyst system for Sandmey...
This Letter presents a facile alternativ...
Primary and secondary alcohols in soluti...
The synthesis of 4′-hydroxy-4-biphenylpr...
A simple and efficient one-pot protocol ...
Carbon dioxide, being one of the major g...
Tetrapropylammonium nonabromide (Pr4NBr9...
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We developed a mild aromatic halogenatio...
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Hydrochloric acid activates the oxidativ...
Electrophilic aromatic bromination of ph...
The oxidation of halogen anions by dimet...
Vanadium pentoxide, V2O5, catalyses the ...
Direct bromination and iodination of var...
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Thiohydroxamic esters (mixed anhydrides)...
A mild and versatile procedure for the b...
The vanadium-catalyzed oxidative bromina...
The monobromination of alkoxybenzenes wi...
A simple, efficient, and rapid method wa...
An ionic compound, bis[1-methyl-3-(3′-su...
An efficient catalytic oxidative bromina...
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A practical synthetic method for the syn...
A convenient and efficient procedure for...
Novel multifunctional ionic liquids (ILs...
The synthesis of a series of banana-shap...
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rac-1-(4-methoxyphenyl)-ethanol
1-bromo-4-methoxy-benzene
3-bromo-4-methoxyacetophenone
1-(4-methoxyphenyl)ethanone
| Conditions | Yield |
|---|---|
|
With
PE-N-oxyl; sodium hydrogencarbonate; sodium bromide;
at 5 ℃;
Electrolysis;
|
38% 36% 3% |
rac-1-(4-methoxyphenyl)-ethanol
1-bromo-4-methoxy-benzene
3-bromo-4-methoxyacetophenone
3-bromo-α-methyl-4-methoxybenzenemethanol
1-(4-methoxyphenyl)ethanone
| Conditions | Yield |
|---|---|
|
Et3N-WS-TEMPO bromide;
In
water;
at 0 ℃;
Electrochemical reaction;
|
49% 4% 8% 6% |
|
With
polymer-immobilized TEMPO radical; sodium hydrogencarbonate; sodium bromide;
In
water;
at 0 ℃;
Electrochemical reaction;
|
22% 19% 19% 12% |
methanol
(4-bromophenyl)diazonium chloride
sodium 4-bromophenoxide
phosgene
4'-(4-methoxyphenoxy)benzoic acid
4-methoxy-4'-ethoxycarbonyl-diphenyl ether
4-bromo-2-chloro-1-methoxybenzene
methoxybenzene