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Hexane-1,2-diol

  • Product Name: Hexane-1,2-diol
  • CasNo: 6920-22-5
  • Purity:
  • Appearance: clear colorless to light yellow liquid

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CasNo: 6920-22-5

Molecular Formula: C6H14O2

Appearance: clear colorless to light yellow liquid

Factory Sells Best Quality Hexane-1,2-diol 6920-22-5 with stock

  • Molecular Formula:C6H14O2
  • Molecular Weight:118.176
  • Appearance/Colour:clear colorless to light yellow liquid 
  • Vapor Pressure:0.0194mmHg at 25°C 
  • Melting Point:45oC 
  • Refractive Index:n20/D 1.442(lit.)  
  • Boiling Point:223.499 °C at 760 mmHg 
  • PKA:14.49±0.20(Predicted) 
  • Flash Point:95.818 °C 
  • PSA:40.46000 
  • Density:0.961 g/cm3 
  • LogP:0.52980 

DL-1,2-Hexanediol(Cas 6920-22-5) Usage

Preparation

1,2-Hexanediol was prepared in about 45% over-all yield by a-bromination of caproic acid, hydrolysis to a-hydroxycaproic acid, and reduction with lithium aluminum hydride.Using the oxidant of H2O2, the organic acid is oxidized to peroxyacid, and the peroxyacid then epoxidizes the olefin double bond, and finally hydrolyzes to obtain 1,2-hexanediol.

benefits

1,2 hexanediol is most commonly used as a solvent in skincare formulation. It pulls the moisture up from the deeper levels of the skin, as well as from the air, to help keep the top layers of your skin from drying out. This makes It very effective at keeping your skin hydrated and providing long-term moisture. It can also help to disperse pigments more evenly in makeup products and boost the antimicrobial activity of preservatives.

Flammability and Explosibility

Nonflammable

Safety

1,2 hexanediol has been proven to be a completely safe and non-irritating ingredient. In an in-use safety evaluation for skin irritation and sensitization potential, 28 participants (males and females) were instructed to use a body wash containing 0.15% 1,2- hexanediol for a minimum of 3 times per week over a 30-day period. There was no evidence of erythema, edema, or dryness of application sites in any of the participants, and it was concluded that the product did not demonstrate a potential for eliciting skin irritation or sensitization.?

Purification Methods

Fractionally distil it, preferably in a vacuum. Alternatively, dissolve it in Et2O, dry with K2CO3 then Na2SO4, filter, evaporate and distil it in a vacuum. The bis-4-nitrobenzoyl derivative has m 101.5-102.5o. [Rudloff Can J Chem 36 486 1958, Beilstein 1 I 251, 1 III 2200, 1 IV 2554.]

Definition

1,2-Hexanediol is a linear aliphatic diol with a carbon chain length containing six carbons. It is a synthetic preservative and moisture-binding agent belonging to a class of agents known as higher molecular glycols. It is considered non-sensitizing. It is ideal for use as an emollient, humectant, and wetting agent in cosmetic and skin care products.

General Description

1,2-Hexanediol acts as cosurfactant, used for modifying the sodium dodecyl sulfate micelles. Solubility of 1,2-hexanediol in supercritical CO2 has been reported. It has a tendency of self-association to form micelle-like aggregates.

InChI:InChI=1/C6H14O2/c1-2-3-4-6(8)5-7/h6-8H,2-5H2,1H3/t6-/m1/s1

6920-22-5 Relevant articles

Chromium-Catalyzed Production of Diols From Olefins

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Paragraph 0111, (2021/03/19)

Processes for converting an olefin react...

A METHOD FOR PREPARING 1,2-HEXANEDIOL

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Paragraph 0040; 0064-0071; 0076, (2021/10/27)

The present invention provides a colourl...

Sterically controlling 2-carboxylated imidazolium salts for one-step efficient hydration of epoxides into 1,2-diols

Cheng, Weiguo,Dong, Li,Fu, Mengqian,Su, Qian,Tan, Xin,Yao, Xiaoqian,Ying, Ting,Zhang, Suojiang

, p. 2992 - 3000 (2021/05/07)

In order to overcome the disadvantages o...

Diol-Ritter Reaction: Regio- And Stereoselective Synthesis of Protected Vicinal Aminoalcohols and Mechanistic Aspects of Diol Monoester Disproportionation

Abboud, Khalil A.,Cheng, Kevin,Klosin, Jerzy,Kruper, William J.,Kruper, William R.,Lysenko, Ivan,Ondari, Mark E.,Thomas, Pulikkottil J.

, (2021/10/20)

The well-known epoxide-Ritter reaction g...

6920-22-5 Process route

2,5-bis-(hydroxymethyl)furan
1883-75-6

2,5-bis-(hydroxymethyl)furan

2,5-dimethyltetrahydrofuran
1003-38-9

2,5-dimethyltetrahydrofuran

2,5-dimethylfuran
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2,5-dimethylfuran

Hexane-1,2-diol
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Hexane-1,2-diol

2-hydroxymethyl-5-methylfuran
3857-25-8

2-hydroxymethyl-5-methylfuran

Conditions
Conditions Yield
With hydrogen; In ethanol; at 220 ℃; for 3h; under 37503.8 Torr;
5-Methylfurfural
620-02-0

5-Methylfurfural

2,5-dimethyltetrahydrofuran
1003-38-9

2,5-dimethyltetrahydrofuran

2,5-dimethylfuran
625-86-5

2,5-dimethylfuran

Hexane-1,2-diol
6920-22-5

Hexane-1,2-diol

2-hydroxymethyl-5-methylfuran
3857-25-8

2-hydroxymethyl-5-methylfuran

Conditions
Conditions Yield
With hydrogen; In butan-1-ol; at 199.84 ℃; for 3h; under 22502.3 Torr; Autoclave;

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